NLINKN1 Chip+PRIME.StudySYNCRStentrode+$75M.SeriesDPRECNLayer 7+FDA.BrkthruPARAMArgo+$20M.SeriesBBLKRKNeuroport+200.ImplantsEMTIVMN8+$45M.SeriesBKRNLFlux+Non-invasiveNRBLEHalo+Consumer.BCINEURONeuroPace+RNS.SystemCOGNICognixion+ALS.TrialFUND.YTD2026$2.8B.SectorTRIALSActive50+.ClinTrialsIMPLNTSHumans~100.Intracrtnl
Terminal/Device DB/Intelligent Neuromodulation System (INNS)
ECoGbreakthroughinvestigational

Intelligent Neuromodulation System (INNS)

Implant Type
ECoG
Electrodes
1,024
Channels
1,024
FDA Status
breakthrough
Clinical Stage
First-in-human safety study (Manchester, UK); 4 patients completed
Status
investigational
About

INBRAIN's BCI is the world's first graphene-based brain-computer interface, featuring ultra-thin (10 micrometer) flexible electrodes that conform to the brain surface with micrometer-scale precision. Graphene's carbon-based composition enables 200x greater charge injection than metal electrodes without Faradaic degradation, supporting millions of stimulation pulses. The platform provides bidirectional, closed-loop neural decoding and modulation with up to 1,024 contacts. In first-in-human studies at Manchester Centre for Clinical Neurosciences, the device captured distinct high-gamma activity linked to different phonemes and differentiated healthy from cancerous brain tissue. FDA Breakthrough Device Designation was granted in 2023 for Parkinson's disease treatment.

Target Conditions
Parkinson's diseaseepilepsystroke rehabilitationbrain tumor mapping
Milestones
2019-01INBRAIN Neuroelectronics founded in Barcelona
2023-01FDA Breakthrough Device Designation for Parkinson's therapy
2024-06$50M Series B funding round
2025-01World's first human graphene BCI procedure at Manchester
2025-06Named 2025 World Economic Forum Technology Pioneer
2025-09Strategic collaboration with Microsoft for agentic AI on Azure
2025-09Collaboration agreement with Mayo Clinic
FDA Regulatory Pathway
Breakthrough Device Designation

FDA Breakthrough Device Designation provides more interactive communication with FDA during development and a priority review pathway. The device is still under investigation and not yet approved for commercial sale.

FDA Device Regulatory Guidance ↗
Other ECoG Devices